TIOTROPIUM BROMIDE

PRODUCT IDENTIFICATION
CAS NO. 136310-93-5 (bromide)
186691-13-4 (base)		TIOTROPIUM BROMIDE 
EINECS NO.  
FORMULA C19H22NO4S2.Br
MOL WT. 472.42

TOXICITY

  

H.S. CODE

  
SYNONYMS Tiotropium bromide; Spiriva; Spiriva Handihaler;
7-((Hydroxybis(2-thienyl)acetyl)oxy)-9,9-dimethyl-3-oxa-9-azoniatricyclo (3.3.1.0(2,4))nonane bromide; (1alpha,2beta,4beta,5alpha,7beta)- 7-((Hydroxydi-2-thienyl acetyl) oxy)-9,9-dimethyl- 3-oxa-9-azonia tricyclo (3,3.1.0(2,4))nonane bromide;
SMILES [BrH-].O(C(=O)C(c1sccc1)(O)c1cccs1)C1C[C@@H]2[C@H]3O [C@H]3[C@H] (C1)[N+]2(C)C

CLASSIFICATION

Antiasthmatic agent, Autonomic agent, Bronchodilator agent, Cholinergic antagonist, Parasympatholytic,

EXTRA NOTES

 Anticholinergic used in the treatment of chronic obstructive disease.

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE

white to off-white crystalline powder

MELTING POINT

217 - 227 C

BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER

Slightly soluble

SOLVENT SOLUBILITY

Slightly soluble in ethanol and acetonitrlie ,soluble in chloroform

pH 4.0 - 7.0
VAPOR DENSITY

 

REFRACTIVE INDEX

  

NFPA RATINGS

 

AUTOIGNITION

 

FLASH POINT

 

STABILITY Stable under normal conditions.

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - Tiotropium bromide

http://www.ncbi.nlm.nih.gov/
Tiotropium, a novel muscarinic M3 receptor antagonist, improved symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure.

http://www.nyrdtc.nhs.uk/
Tiotropium is a long-acting inhaled antimuscarinic bronchodilator for the maintenance treatment of chronic obstructive pulmonary disease (COPD). Its prolonged duration of action is due to persistent binding to bronchial muscarinic M3 receptors, which is significantly longer than that of ipratropium1. It has a slow onset of action (1 - 2 hours), making it unsuitable for acute symptomatic relief2. The recommended dose is 18 mcg once daily, taken at the same time each day. It is administered via a breath-actuated dry powder inhaler.

http://www.medilexicon.com/
Mechanism of action: Tiotropium is an antimuscarinic agent or anticholinergic with similar affinity to the subtypes of muscarinic receptors, M1 to M5. The drug inhibits M3-receptors at the smooth muscle leading to bronchodilation. The HandiHaler is an inhalation device used to inhale the dry powder contained Spiriva capsules. The capsule is pierced by the device, dispersing tiotropium into the air stream.
SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

IDENTIFICATION

passes Test A, B

ASSAY

99.0% min
MELTING POINT

217 - 227 C
LOSS ON DRYING

1.0% max

IMPURITY

1.0% max

pH

4.0 - 7.0

HEAVY METALS

20ppm max

RESIDUE ON IGNITION

0.1% max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
PRICE INFORMATION